Two men were shot while traveling along eastbound Interstate 8 in La Mesa early Sunday.
The California Highway Patrol responded to a call just before 4 a.m. reporting a person on the road next to a vehicle on I-8 near the junction with State Route 125.
Officials say two men in their 20s were brought to Grossmont Hospital with gunshot wounds around the same time.
The men were in serious conditions and were transported to another nearby hospital because of the seriousness of their injuries La Mesa police Lt. Matt Nicholas said.
Officials believe a vehicle pulled alongside the victims’ vehicle and fired multiple shots at the victims.
Investigators have not released a motive or a description of the suspect’s vehicle.
CHP officers closed down a portion of I-8 to traffic for more than five hours Sunday morning as they combed the highway for evidence in the shooting.
Traffic has been reopened along I-8 from 70th Street to Severin Drive.